OönaPMS1 is formulated with herbs to help regulate production of hormones and, in turn, the menstrual cycle.* OönaPMS1 daily tablet is comprised primarily of chaste tree berry based with added black cohosh. Neither black cohosh or chaste tree berry contain hormones or hormone-like substances; however the herbs do influence hormonal activity through the pituitary gland and hypothalamus.* In part, chaste tree berry has been shown to stimulate the brain to produce more of the luteinizing hormone (LH).* Greater production of LH in turn signals the ovaries to produce more progesterone and thus balance the ratio of progesterone to estrogen. This leads to relief for many women who may find themselves irritable, depressed, and bloated right before their period. Chaste tree berry has also been used successfully for menstruation related acne.*

Another benefit of chaste tree berry is its ability to lower prolactin levels.* Elevated prolactin levels have been associated with PMS symptoms such as breast tenderness. The lowering of prolactin concentrations in turn also raises progesterone levels. It is this hormone balancing combination of lower prolactin and greater LH production that not only offers many women significant PMS relief but also a side benefit of achieving more regular ovulation.* While chaste tree can do wonders to normalize a the menstrual cycle, OonaPMS1 should not be taken or stopped immediately if you think you may be pregnant.

The black cohosh in OönaPMS1, a great counterpart to chaste tree berry,* also helps to normalize hormone production via the pituitary gland. Although the herb is known mostly for its aid of the symptoms of perimenopause, it has also been shown to help alleviate PMS symptoms such as anxiety, tension, and depression. One noted mechanism is that black cohosh helps regulate estrogen levels in part by binding to estrogen receptors.* Another indicates that it runs interference with neurotransmitters.* Although more research is needed to determine the complex way in which this herb works, black cohosh has long-established benefits for women's hormonal health.

Finally, we've added a "bonus supplement" of passionflower for women who need a little extra relief. Taken just after ovulation ends, passionflower extract is a great complement to chaste tree berry for women who feel especially irritable and depressed just prior to menstruation.* Passionflower has historically been used as a calming agent, and is particularly helpful when physical or mental strain results in stress.* It is not a strong pain reliever but does have a lasting and refreshing effect on the nervous system.* Although scientists do not know the exact compound or group of compounds that give passionflower its medicinal value, it is clear that the flavoniods such as vitexin play an important role. In Europe passionflower is required to contain no less than .4% total flavonoids calculated as vitexin This is the same standard is applied to OönaPMS1.

OönaPMS2 is formulated to address the frequent onset of PMS menstrual cramps and associated headaches and/or gastrointestinal complaints.* OönaPMS2 is a combination of an Oöna Health, Inc. proprietary cramp bark extract called Oöna Bark™ and standardized ginger extract. The active constituents of cramp bark have been identified as coumarins (such as scopoletin and scopolin), tannins (primarily catechins) and verbenalin, a known smooth muscle relaxant.* (the uterus is made up of smooth muscle) Indigenous to North America, cramp bark is a large shrub that belongs to the same family as the Elder. Today, cramp bark is mostly collected in northern Europe. Cramp bark has a long history of use in easing menstrual cramps by working as a uterine relaxant and general antispasmodic.* It dates back to Native American tribal use and was also listed in The National Formulary for many years for this use. OönaPMS2 is standardized to the marker compound verbenalin.

Possibly one of the first plants to be cultivated by humankind, ginger is valued by nearly every culture around the globe. While ginger has long been known for its ability to calm an upset stomach, it can also help ease menstrual cramps and any gastrointestinal discomfort that may accompany the onset of a woman's period.* Most of ginger's therapeutic effects come from an oil called gingerol. Gingerol eases menstrual cramps by lowering a hormone-like substance known as prostaglandins.* As explained above, it is the overproduction of prostaglandins that has been shown to cause menstrual cramps.